Dengue Virus Net is the web resource for anyone interested in dengue. Dengue is a mosquito-borne infection that causes a severe flu-like illness (dengue fever), and sometimes a potentially lethal complication called dengue haemorrhagic fever. Global incidence of dengue has grown dramatically in recent decades. About two fifths of the world's population are now at risk. Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas. Dengue is transmitted to humans by the Aedes aegypti or more rarely the Aedes albopictus mosquito, which feed during the day. Dengue haemorrhagic fever is a leading cause of serious illness and death among children in some Asian countries. A vaccine for dengue fever has been approved by the FDA in May 2019 and is commercially available in a number of countries.

The objectives of Dengue Virus Net are to be the public and professional information resource for dengue and to serve as a network in the exchange of information and news related to dengue.

• Indonesia’s plan to release 200 million special mosquitoes to fight dengue in Bali sparks ‘lab rats’ criticism - South China Morning Post
  Wed, 06 Dec 2023 00:30 GMT
• World's first 'dengue dashboard' could predict outbreaks months before they happen - The Telegraph
  Mon, 04 Dec 2023 13:34 GMT
• U.S. Reissued Dengue Outbreak Travel Health Notice — Precision Vaccinations News - Precision Vaccinations
  Mon, 04 Dec 2023 17:47 GMT
• As temperatures rise, dengue fever infections keep surging around the world - CBC.ca
  Sat, 02 Dec 2023 09:00 GMT
• As Temperatures Rise, Dengue Fever Spreads and Cases Rise - Yale Environment 360
  Thu, 30 Nov 2023 09:32 GMT
• Bangladesh battles record dengue deaths as disease pattern changes - Al Jazeera English
  Tue, 21 Nov 2023 08:00 GMT
• Dengue is spreading. Can new vaccines and antivirals halt its rise? - Nature.com
  Tue, 07 Nov 2023 08:00 GMT
• Jamaica’s dengue fever outbreak shows the deadly effects of record heat - The Guardian
  Thu, 16 Nov 2023 08:00 GMT
• Epidemiological Alert - Sustained circulation of dengue in the Region of the Americas - 5 December 2023 - Pan American Health Organization
  Tue, 05 Dec 2023 23:09 GMT
• Epidemiological Alert - Sustained circulation of dengue in the Region of the Americas - 5 December 2023 - World - ReliefWeb
  Tue, 05 Dec 2023 23:59 GMT
• Dengue spikes: the view from West Bengal - Gavi, the Vaccine Alliance
  Fri, 01 Dec 2023 17:54 GMT
• As dengue expands beyond the global 'dengue belt,' scientists dispel conventional wisdom about the disease - Medical Xpress
  Fri, 01 Dec 2023 14:00 GMT
• Interactions between DC-SIGN and the envelope protein from Dengue and Zika viruses: a structural perspective based ... - Virology Journal
  Mon, 04 Dec 2023 20:48 GMT
• Early Release - Autochthonous Dengue Fever in 2 Patients, Rome, Italy - Volume 30, Number 1—January 2024 ... - CDC
  Wed, 15 Nov 2023 08:00 GMT
• Tackling dengue one house at a time in Asunción - Pan American Health Organization
  Mon, 04 Dec 2023 21:22 GMT

• PRO/AH/EDR> Invasive mosquito - France (03): (BT)
  Mon, 06 Sep 2021 21:28:53 -0400
  Yellow Fever, Zika virus, Dengue, Chikungunya -- France
  A potentially deadly mosquito that can carry viruses such as yellow fever and Zika has been spotted in Brittany, northern France, sparking fears they may soon land on British shores. Asian tiger mosquitoes [_Aedes albopictus_] have been confirmed to be in the commune of Domagne in the department of Ile-et-Vilaine in western Brittany.
  Health authorities are preparing an intensive campaign to rid the area of the insects with strong insecticides.
  The creatures were 1st seen in France in the

• Syncytial and Congregative Effects of Dengue and Zika Viruses on the Aedes Albopictus Cell Line Differ among the Viral Strains Tue, 05 Dec 2023 06:00:00 -0500
  CONCLUSION: Syncytial and congregative effects of DENV and ZIKV on the Aedes albopictus cells differ among the viral strains. Syncytial effects of DENV on C6/36 are important for viral replication.
• Exploring the viral protease inhibitor space driven by consensus scoring-based virtual screening Tue, 05 Dec 2023 06:00:00 -0500
  Dengue fever presents a major health concern, and the lack of an effective vaccine or definite therapeutic regimen has led the research community to identify safe-by-design potential targets for drug discovery. Since the association of the NS2B co-factor with the protease domain of NS3 is imperative for the catalytic activity of the enzyme complex, inhibitors blocking their interaction could provide an alternative strategy to combat the dengue virus. In this context, the present study is aimed...
• Interactions between DC-SIGN and the envelope protein from Dengue and Zika viruses: a structural perspective based on molecular dynamics and MM/GBSA analyses Mon, 04 Dec 2023 06:00:00 -0500
  Zika virus (ZIKV) and dengue virus (DENV) share a lot of similarities being both phylogenetically closely related, share the same insect vector passage for reaching the host, affinity for the same carbohydrate receptor domains (CRDs), indicating feasible competition between them on the natural field. Here, we prospected interactions of both envelope proteins with a DC-SIGN, a transmembrane c-type lectine receptor with the most implicated CRD with the Flavivirus infection presents on dendritic...
• Acceptability of a hypothetical dengue vaccine and the potential impact of dengue vaccination on personal vector control behavior: a qualitative study in Fortaleza, Brazil Mon, 04 Dec 2023 06:00:00 -0500
  CONCLUSIONS: Our study findings provide community-level perspectives on dengue vaccination and its potential impact on personal vector control behavior for policymakers and program managers in Fortaleza to consider as new dengue vaccines become available. With the introduction of any new dengue vaccine, community perspectives and emerging concerns that may drive vaccine hesitancy should be continuously sought out. Improved urban infrastructure and efforts to engage individuals and communities in...
• Development of a tetravalent subunit vaccine against dengue virus through a vaccinomics approach Mon, 04 Dec 2023 06:00:00 -0500
  Dengue virus infection (DVI) is a mosquito-borne disease that can lead to serious morbidity and mortality. Dengue fever (DF) is a major public health concern that affects approximately 3.9 billion people each year globally. However, there is no vaccine or drug available to deal with DVI. Dengue virus consists of four distinct serotypes (DENV1-4), each raising a different immunological response. In the present study, we designed a tetravalent subunit multi-epitope vaccine, targeting proteins...
• Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study Sun, 03 Dec 2023 06:00:00 -0500
  Antiparasitic ivermectin has been reported to induce cardiovascular adverse events, including orthostatic hypotension, tachycardia and cardiopulmonary arrest, of which the underlying pathophysiology remains unknown. Since its drug repurposing as an antiviral agent is underway at higher doses than those for antiparasitic, we evaluated the cardiovascular safety pharmacology of ivermectin using isoflurane-anesthetized beagle dogs (n=4). Ivermectin in doses of 0.1 followed by 1 mg/kg was...
• Biological evaluation of 1,3-benzodioxole acids points to 3,4-(methylenedioxy) cinnamic acid as a potential larvicide against Aedes aegypti (Diptera: Culicidae) Sun, 03 Dec 2023 06:00:00 -0500
  Aedes aegypti serves as the primary vector for viruses like dengue, Chikungunya, Zika, and yellow fever, posing a significant public health challenge in Brazil. Given the absence of approved vaccines for these diseases, effective mosquito control becomes paramount in preventing outbreaks. However, currently available chemical insecticides face issues related to toxicity and the emergence of resistance, necessitating the exploration of new active compounds. Drawing inspiration from natural...
• A multiparametric and orthogonal approach indicates low toxicity for zein nanoparticles in a repellent formulation Sun, 03 Dec 2023 06:00:00 -0500
  The incidence of viruses such as Zika, Dengue, and Chikungunya affects human health worldwide, and insect repellents are recommended for individual protection. Formulations incorporating nanotechnology should be carefully assessed for toxicity, particularly regarding the security levels established for human health and the environment. This study evaluates the cytotoxicity of a repellent formulation containing zein nanoparticles (NP) loading geraniol (Ger) and icaridin (Ica) in three cell lines:...
• Joint spatial modeling of the risks of co-circulating mosquito-borne diseases in Ceará, Brazil Sat, 02 Dec 2023 06:00:00 -0500
  Mosquito-borne diseases such as dengue and chikungunya have been co-circulating in the Americas, causing great damage to the population. In 2021, for instance, almost 1.5 million cases were reported on the continent, being Brazil the responsible for most of them. Even though they are transmitted by the same mosquito, it remains unclear whether there exists a relationship between both diseases. In this paper, we model the geographic distributions of dengue and chikungunya over the years 2016 to...
• IgM-specific linear epitopes on the E2 protein for serodiagnosis of Chikungunya Sat, 02 Dec 2023 06:00:00 -0500
  Chikungunya virus (CHIKV) and Dengue virus (DENV) are vector-borne diseases transmitted by Aedes aegypti and Aedes albopictus that pose a significant threat to global public health. Cases of acute Chikungunya fever often present similar clinical symptoms to other vector-borne diseases such as Dengue fever. In regions where multiple vector-borne diseases coexist, CHIKV is often overlooked or misdiagnosed as Dengue virus, West Nile virus, Zika virus or other viral infections, which delays its...