Dengue Virus Net is the web resource for anyone interested in dengue. Dengue is a mosquito-borne infection that causes a severe flu-like illness (dengue fever), and sometimes a potentially lethal complication called dengue haemorrhagic fever. Global incidence of dengue has grown dramatically in recent decades. About two fifths of the world's population are now at risk. Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas. Dengue is transmitted to humans by the Aedes aegypti or more rarely the Aedes albopictus mosquito, which feed during the day. Dengue haemorrhagic fever is a leading cause of serious illness and death among children in some Asian countries. A vaccine for dengue fever has been approved by the FDA in May 2019 and is commercially available in a number of countries.

The objectives of Dengue Virus Net are to be the public and professional information resource for dengue and to serve as a network in the exchange of information and news related to dengue.

• Infographic: What is dengue and how does it spread? - Aljazeera.com
  Tue, 09 Nov 2021 08:00 GMT
• Dengue: When Does Dengue Become Fatal? What Are The Warning Signs? - NDTV
  Mon, 22 Nov 2021 08:00 GMT
• Punjab second worst hit by dengue in the country - Times of India
  Wed, 01 Dec 2021 01:42 GMT
• State reports 3,900 dengue cases this year - The Hindu
  Tue, 30 Nov 2021 19:31 GMT
• Distortion: Researchers discover new strategy for antibodies to disable viruses - Penn State News
  Tue, 30 Nov 2021 20:26 GMT
• 69 more people hospitalised with dengue - newagebd.net
  Tue, 30 Nov 2021 18:34 GMT
• Dengue's dance: Host immunity drives viral evolution - Science Daily
  Thu, 18 Nov 2021 08:00 GMT
• Experts warn of dengue outbreak in Chennai following waterlogging in city - Business Standard
  Wed, 01 Dec 2021 08:23 GMT
• 12 new dengue cases in Mohali - The Tribune
  Wed, 01 Dec 2021 02:47 GMT
• 3 cases of dengue and 2 of influenza have been registered so far this year in Yucatan - The Yucatan Times
  Mon, 29 Nov 2021 20:14 GMT
• India Dengue Outbreak Shows Covid Pandemic Lessons Not Learned - Bloomberg
  Sun, 07 Nov 2021 07:00 GMT
• How to navigate this dengue season - Times of India
  Fri, 12 Nov 2021 08:00 GMT
• New evidence that host immunity drives evolution of the dengue virus - News-Medical.net
  Sat, 20 Nov 2021 08:00 GMT
• Final Evaluation - Central America: Dengue Outbreak Emergency Appeal (MDR42005) - Honduras - ReliefWeb
  Tue, 16 Nov 2021 08:00 GMT
• Kolkata's fight against dengue: Eye in the sky to spot stagnant water in Salt Lake houses - Times of India
  Mon, 29 Nov 2021 22:42 GMT

• PRO/AH/EDR> Invasive mosquito - France (03): (BT)
  Mon, 06 Sep 2021 21:28:53 -0400
  Yellow Fever, Zika virus, Dengue, Chikungunya -- France
  A potentially deadly mosquito that can carry viruses such as yellow fever and Zika has been spotted in Brittany, northern France, sparking fears they may soon land on British shores. Asian tiger mosquitoes [_Aedes albopictus_] have been confirmed to be in the commune of Domagne in the department of Ile-et-Vilaine in western Brittany.
  Health authorities are preparing an intensive campaign to rid the area of the insects with strong insecticides.
  The creatures were 1st seen in France in the

• Revisiting dengue virus-mosquito interactions: molecular insights into viral fitness Tue, 30 Nov 2021 06:00:00 -0500
  Dengue virus (DENV), like other viruses, closely interacts with the host cell machinery to complete its life cycle. Over the course of infection, DENV interacts with several host factors with pro-viral activities to support its infection. Meanwhile, it has to evade or counteract host factors with anti-viral activities which inhibit its infection. These molecular virus-host interactions play a crucial role in determining the success of DENV infection. Deciphering such interactions is thus...
• Geometric morphometric wing analysis as a tool to discriminate female mosquitoes from different suburban areas of Chiang Mai province, Thailand Mon, 29 Nov 2021 06:00:00 -0500
  Mosquitoes are hematophagous insects that transmit parasites and pathogens with devastating effects on humans, particularly in subtropical regions. Different mosquito species display various behaviors, breeding sites, and geographic distribution; however, they can be difficult to distinguish in the field due to morphological similarities between species and damage caused during trapping and transportation. Vector control methods for controlling mosquito-borne disease epidemics require an...
• Identification of a Novel Series of Potent Organosilicon Mosquito Repellents Mon, 29 Nov 2021 06:00:00 -0500
  Mosquito control by personal protection is one of the most efficient ways of curtailing deadly diseases such as malaria and dengue with the potential to save millions of lives per year. DEET (N,N-diethyl-3-methyl benzamide) is currently considered as the gold standard for mosquito repellents, being used for the past several decades. Control by DEET, however, is being threatened by emerging resistance among mosquitoes. To address this concern and also to improve protection times, we synthesized a...
• IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis Mon, 29 Nov 2021 06:00:00 -0500
  Dengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead to cellular dysfunction in tissue/organ failures and often facilitate severe dengue disease in patients. Interleukin- (IL-) 18, similar to IL-1β, is a proinflammatory cytokine produced during...
• Mortality Rates of Severe Dengue Viral Infection Before and After Implementation of a Revised Guideline for Severe Dengue Mon, 29 Nov 2021 06:00:00 -0500
  CONCLUSIONS: Although following the revised guidelines could not prevent organ failure, the mortality rates in patients with multiorgan failure and/or ACS decreased significantly when following the revised guidelines.
• Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (13)-beta-D-Glucan in Severe Dengue Infection Sat, 27 Nov 2021 06:00:00 -0500
  The hallmark of severe dengue infection is the increased vascular permeability and hemodynamic alteration that might be associated with an intestinal permeability defect. However, the mechanisms underlying the gastrointestinal-related symptoms of dengue are not well characterized. A prospective observational study was conducted on patients with dengue who were categorized according to: (i) febrile versus critical phase and (ii) hospitalized patients with versus without the warning signs to...
• Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR Sat, 27 Nov 2021 06:00:00 -0500
  Since its first detection in 1979, dengue fever has been considered a major public health issue in the Lao People's Democratic Republic (PDR). Dengue virus (DENV) serotype 1 was the cause of an epidemic in 2010-2011. Between 2012 and 2020, major outbreaks due successively to DENV-3, DENV-4 and recently DENV-2 have been recorded. However, DENV-1 still co-circulated in the country over this period. Here, we summarize epidemiological and molecular data of DENV-1 between 2016 and 2020 in the Lao...
• Genotype-Dependent Immunogenicity of Dengue Virus Type 2 Asian I and Asian/American Genotypes in Common Marmoset (Callithrix jacchus): Discrepancy in Neutralizing and Infection-Enhancing Antibody Levels between Genotypes Sat, 27 Nov 2021 06:00:00 -0500
  Owing to genotype-specific neutralizing antibodies, analyzing differences in the immunogenic variation among dengue virus (DENV) genotypes is central to effective vaccine development. Herein, we characterized the viral kinetics and antibody response induced by DENV type 2 Asian I (AI) and Asian/American (AA) genotypes using marmosets (Callithrix jacchus) as models. Two groups of marmosets were inoculated with AI and AA genotypes, and serial plasma samples were collected. Viremia levels were...
• Optimization of Flow-Cytometry Based Assay for Measuring Neutralizing Antibody Responses against Each of the Four Dengue Virus Serotypes Sat, 27 Nov 2021 06:00:00 -0500
  Dengue is an important public health problem worldwide, with India contributing nearly a third of global dengue disease burden. The measurement of neutralizing antibody responses is critical for understanding dengue pathophysiology, vaccine development and evaluation. Historically, dengue virus neutralization titers were measured using plaque reduction neutralization tests (PRNTs), which were later adapted to focus reduction neutralization tests (FRNTs). Given the slow and laborious nature of...
• Developing a Stabilizing Formulation of a Live Chimeric Dengue Virus Vaccine Dry Coated on a High-Density Microarray Patch Sat, 27 Nov 2021 06:00:00 -0500
  Alternative delivery systems such as the high-density microarray patch (HD-MAP) are being widely explored due to the variety of benefits they offer over traditional vaccine delivery methods. As vaccines are dry coated onto the HD-MAP, there is a need to ensure the stability of the vaccine in a solid state upon dry down. Other challenges faced are the structural stability during storage as a dried vaccine and during reconstitution upon application into the skin. Using a novel live chimeric virus...