Dengue Virus Net is the web resource for anyone interested in dengue. Dengue is a mosquito-borne infection that causes a severe flu-like illness (dengue fever), and sometimes a potentially lethal complication called dengue haemorrhagic fever. Global incidence of dengue has grown dramatically in recent decades. About two fifths of the world's population are now at risk. Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas. Dengue is transmitted to humans by the Aedes aegypti or more rarely the Aedes albopictus mosquito, which feed during the day. Dengue haemorrhagic fever is a leading cause of serious illness and death among children in some Asian countries. A vaccine for dengue fever has been approved by the FDA in May 2019 and is commercially available in a number of countries.

The objectives of Dengue Virus Net are to be the public and professional information resource for dengue and to serve as a network in the exchange of information and news related to dengue.

• Dengue Virus - Wisconsin Department of Health Services
  Wed, 15 Jun 2022 07:00 GMT
• Mapping Mexico's dengue fever hotspots: Rutgers researcher co ... - Science Daily
  Wed, 01 Feb 2023 23:03 GMT
• Southeast Asia warned of insecticide-resistant dengue mosquitoes - Nikkei Asia
  Sun, 05 Feb 2023 00:30 GMT
• Dominican Republic closed 2022 with 39 deaths due to dengue fever - Prensa Latina
  Sun, 05 Feb 2023 19:06 GMT
• One more dies of Dengue - Dhaka - newagebd.net
  Sun, 05 Feb 2023 12:08 GMT
• Bolivia dengue fever cases continue rise in 2023 - Outbreak News ... - Outbreak News Today
  Sun, 29 Jan 2023 13:49 GMT
• Strategy required to sustain Dengue vector control | RMHP - Dove Medical Press
  Wed, 01 Feb 2023 13:00 GMT
• Republic of Sudan: Dengue Fever Sitrep – 28 July 2022 - 28 Jan ... - ReliefWeb
  Tue, 31 Jan 2023 12:40 GMT
• Antibody “fingerprinting” method potential advance to slow spread of ... - VUMC Reporter
  Thu, 12 Jan 2023 08:00 GMT
• Dengue spikes in Brazil - CGTN America
  Thu, 02 Feb 2023 21:08 GMT
• Sinococuline, a bioactive compound of Cocculus hirsutus has potent ... - Nature.com
  Thu, 19 Jan 2023 08:00 GMT
• Alphabet's Verily seeks to eradicate dengue in Singapore - Financial Times
  Sat, 07 Jan 2023 08:00 GMT
• Singapore on alert for fresh dengue fever outbreak - 9News
  Tue, 31 Jan 2023 01:06 GMT
• Dengue Burden and Circulation of Dengue-2 Serotype Among ... - Cureus
  Wed, 18 Jan 2023 08:00 GMT
• Dengue fever: 14 hospitalised in 24 hours - The Daily Star
  Tue, 24 Jan 2023 11:19 GMT

• PRO/AH/EDR> Invasive mosquito - France (03): (BT)
  Mon, 06 Sep 2021 21:28:53 -0400
  Yellow Fever, Zika virus, Dengue, Chikungunya -- France
  A potentially deadly mosquito that can carry viruses such as yellow fever and Zika has been spotted in Brittany, northern France, sparking fears they may soon land on British shores. Asian tiger mosquitoes [_Aedes albopictus_] have been confirmed to be in the commune of Domagne in the department of Ile-et-Vilaine in western Brittany.
  Health authorities are preparing an intensive campaign to rid the area of the insects with strong insecticides.
  The creatures were 1st seen in France in the

• A bivalent form of nanoparticle-based dengue vaccine stimulated responses that potently eliminate both DENV-2 particles and DENV-2-infected cells Sun, 05 Feb 2023 06:00:00 -0500
  Dengue is the most prevalent mosquito-borne viral disease and continues to be a global public health concern. Although a licensed dengue vaccine is available, its efficacy and safety profile are not satisfactory. Hence, there remains a need for a safe and effective dengue vaccine. We are currently developing a bivalent dengue vaccine candidate. This vaccine candidate is composed of a C-terminus truncated non-structural protein 1 (NS1(1-279)) and envelope domain III (EDIII) of DENV-2 encapsidated...
• The Clinical Utility of CD163 in Viral Diseases Sun, 05 Feb 2023 06:00:00 -0500
  Macrophage activation and hypercytokinemia are notable presentations in certain viral infections leading to severe disease and poor prognosis. Viral infections can cause macrophage polarization into the pro-inflammatory M1 or anti-inflammatory M2 phenotype. Activated M1 macrophages usually restrict viral replication whereas activated M2 macrophages suppress inflammation and promote tissue repair. In response to inflammatory stimuli, macrophages polarize to the M2 phenotype expressing hemoglobin...
• Development of novel antiviral peptides against dengue serotypes 1-4 Sun, 05 Feb 2023 06:00:00 -0500
  Dengue infections pose a critical threat to public health worldwide. Since there are no clinically approved antiviral drugs to treat dengue infections caused by the four dengue virus (DENV) serotypes, there is an urgent need to develop effective antivirals. Peptides are promising antiviral candidates due to their specificity and non-toxic properties. The DENV envelope (E) protein was selected for the design of antiviral peptides due to its importance in receptor binding and viral fusion to the...
• Establishment of quantitative and recovery method for detection of dengue virus in wastewater with noncognate spike control Fri, 03 Feb 2023 06:00:00 -0500
  Wastewater-based epidemiology (WBE) represents an efficient approach for public pathogen surveillance as it provides early warning of disease outbreaks; however, it has not yet been applied to dengue virus (DENV), which might cause endemics via mosquito spread. In this study, a working platform was established to provide direct virus recovery and qPCR quantification from wastewater samples that were artificially loaded with target DENV serotypes I to IV and noncognate spike control viral...
• Antibody cross-reactivity and evidence of susceptibility to emerging Flaviviruses in the dengue-endemic Brazilian Amazon Fri, 03 Feb 2023 06:00:00 -0500
  CONCLUSIONS: Taken together, we observed a high prevalence of DENV in the Manaus-Amazon region and a varying degree of cross-reactivity against emerging and endemic Flaviviruses. Epidemiological and exposure conditions in Manaus makes its population susceptible to emerging and endemic arboviruses .
• The dengue virus 4 component of NIAID's tetravalent TV003 vaccine drives its innate immune signature Fri, 03 Feb 2023 06:00:00 -0500
  Annually, roughly 2.5 billion people are at risk for dengue virus (DENV) infection, and the incidence of infection has increased 30-fold since its discovery in the 1900s. At present, there are no globally licensed antiviral treatments or vaccines that protect against all four of the DENV serotypes. The NIAID Live Attenuated Tetravalent Vaccine (LATV) dengue vaccine candidate is composed of variants of three DENV serotypes attenuated by a 30 nucleotide (Δ30) deletion in the 3' untranslated region...
• Mapping patient pathways and understanding clinical decision-making in dengue management to inform the development of digital health tools Thu, 02 Feb 2023 06:00:00 -0500
  CONCLUSIONS: The study highlights the contemporary priorities in delivering clinical care to patients with dengue in an endemic setting. Key decision-making processes and the sources of information that were of the greatest utility were identified. These findings serve as a foundation for future clinical interventions and improvements in healthcare. Understanding the decision-making process in greater detail also allows for development and implementation of CDSS which are suited to the local...
• The Genetic Variant TNFA (rs361525) Is Associated with Increased Susceptibility to Developing Dengue Symptoms Thu, 02 Feb 2023 06:00:00 -0500
  Dengue virus (DENV) is the causal agent of dengue fever. The symptoms and signs of dengue vary from febrile illness to hemorrhagic syndrome. IFITM3 and TNFA are genes of the innate immune system. Variants IFITM3 (rs12252 T>C) and TNFA (rs1800629 G > A and rs361525 G>A) might alter gene expression and change the course of the disease. Our first objective was to determine whether these variants were associated with the susceptibility and severity of dengue. The second was to assess the association...
• Features of the urban environment associated with Aedes aegypti abundance in high-rise public apartments in Singapore: An environmental case-control study Thu, 02 Feb 2023 06:00:00 -0500
  Aedes aegypti abundance in residential estates is hypothesized to contribute to localised outbreaks of dengue in Singapore. Knowing the factors in the urban environment underlying high Ae. aegypti abundance could guide intervention efforts to reduce Ae. aegypti breeding and the incidence of dengue. In this study, objective data on Ae. aegypti abundance in public apartment blocks estimated by Singapore's nationally representative Gravitrap surveillance system was obtained from the National...
• Quantifying heterogeneities in arbovirus transmission: Description of the rationale and methodology for a prospective longitudinal study of dengue and Zika virus transmission in Iquitos, Peru (2014-2019) Thu, 02 Feb 2023 06:00:00 -0500
  Current knowledge of dengue virus (DENV) transmission provides only a partial understanding of a complex and dynamic system yielding a public health track record that has more failures than successes. An important part of the problem is that the foundation for contemporary interventions includes a series of longstanding, but untested, assumptions based on a relatively small portion of the human population; i.e., people who are convenient to study because they manifest clinically apparent...