Dengue Virus Net is the web resource for anyone interested in dengue. Dengue is a mosquito-borne infection that causes a severe flu-like illness (dengue fever), and sometimes a potentially lethal complication called dengue haemorrhagic fever. Global incidence of dengue has grown dramatically in recent decades. About two fifths of the world's population are now at risk. Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas. Dengue is transmitted to humans by the Aedes aegypti or more rarely the Aedes albopictus mosquito, which feed during the day. Dengue haemorrhagic fever is a leading cause of serious illness and death among children in some Asian countries. A vaccine for dengue fever has been approved by the FDA in May 2019 and is commercially available in a number of countries.

The objectives of Dengue Virus Net are to be the public and professional information resource for dengue and to serve as a network in the exchange of information and news related to dengue.

• Double blow: Bangladesh battles dengue outbreak amid COVID crisis - Al Jazeera English
  Fri, 30 Jul 2021 09:33 GMT
• Global warming may limit spread of dengue fever, new research finds | Penn State University - Penn State News
  Thu, 22 Jul 2021 07:00 GMT
• Lost in post-translational modification—Dengue virus writes its own sequel - Science
  Fri, 02 Jul 2021 07:00 GMT
• Dengue virus could make mosquitoes more vulnerable to rising temperatures - Popular Science
  Thu, 22 Jul 2021 07:00 GMT
• Higher temperatures could limit the spread of dengue infection - News-Medical.Net
  Wed, 28 Jul 2021 00:46 GMT
• Mapping dengue hot spots pinpoints risks for Zika and chikungunya - Emory News Center
  Wed, 07 Jul 2021 07:00 GMT
• Deploying Specialized Mosquitos Successfully Curbs Dengue Incidence - Contagionlive.com
  Fri, 09 Jul 2021 07:00 GMT
• Central America: Dengue Outbreak - Emergency Appeal Final Report (MDR42005) - Honduras - ReliefWeb
  Mon, 26 Jul 2021 20:48 GMT
• Mapping dengue fever hot spots can predict future outbreaks of Zika and chikungunya - News-Medical.Net
  Wed, 07 Jul 2021 07:00 GMT
• Philippines dengue: Pangasinan reports doubling of cases in 2021 - Outbreak News Today - Outbreak News Today
  Sat, 31 Jul 2021 11:37 GMT
• As dengue menaces COVID-hit Bangladesh, children at greater risk - bdnews24.com
  Sun, 01 Aug 2021 07:33 GMT
• Pune Municipal Corporation logs record dengue cases in July - The Indian Express
  Thu, 22 Jul 2021 07:00 GMT
• Climate crisis ‘may put 8bn at risk of malaria and dengue’ - The Guardian
  Thu, 08 Jul 2021 07:00 GMT
• 58 new dengue cases, Bhubaneshwar Municipal Corporation on awareness drive - The New Indian Express
  Sun, 01 Aug 2021 05:48 GMT
• Looking out for dengue this monsoon: Know the symptoms and methods of prevention - Times Now
  Mon, 19 Jul 2021 07:00 GMT

• PRO/AH/EDR> Leptospirosis - Guyana: (EB) flooding
  Sun, 18 Jul 2021 15:52:28 -0400
  Leptospirosis -- Guyana
  Following major flooding in the country, Region 6 is reporting 67 cases of dengue and 5 cases of leptospirosis.
  Regional Chairman, David Armogan, during a press briefing in Region 6 yesterday, relayed that that while there are 67 cases of the mosquito-borne dengue presently there has not been any major escalation since.
  "A number of areas are pretty dry, Black Bush Polder they don't have much difficulties with flooding and so, and a lot of those cases came out from Black Bush too", he

• Risk factors for hospitalization and mortality due to dengue fever in a Mexican population: a retrospective cohort study Sat, 31 Jul 2021 06:00:00 -0400
  CONCLUSION: Identification of risk factors associated with increased hospitalization and mortality due to DF can help categorize patients that require close monitoring and inpatient care. Early identification of warning signs and patients at increased risk is key to avoiding delay of supportive care.
• Viral-induced inflammatory coagulation disorders: Preparing for another epidemic Sat, 31 Jul 2021 06:00:00 -0400
  A number of viral infectious diseases have emerged or reemerged from wildlife vectors that have generated serious threats to global health. Increased international traveling and commerce increase the risk of transmission of viral or other infectious diseases. In addition, recent climate changes accelerate the potential spread of domestic disease. The Coronavirus disease 2019 (COVID-19) pandemic is an important example of the worldwide spread, and the current epidemic will unlikely be the last....
• Fear, mistrust, and vaccine hesitancy: Narratives of the dengue vaccine controversy in the Philippines Sat, 31 Jul 2021 06:00:00 -0400
  This article applies a qualitative approach to the 2017 dengue vaccine controversy involving Sanofi Pasteur's Dengvaxia to understand vaccine hesitancy and related anxieties in contemporary Philippines. Through a multisited project that investigated the health aspirations and lived experiences of low- and middle-income Filipinos across urban and rural Philippines, this article distills the perspectives of both ordinary community members and health workers in local and national capacities...
• Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques Fri, 30 Jul 2021 06:00:00 -0400
  Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV immunity on ZIKV pathogenesis during pregnancy in a translational non-human primate model. Here we show that macaques with a prior DENV-2 exposure had a higher burden of ZIKV vRNA in maternal-fetal...
• Phenotypical characterization of regulatory T cells in acute Zika infection Thu, 29 Jul 2021 06:00:00 -0400
  Zika virus (ZIKV), alongside Dengue virus (DENV), Chikungunya virus (CHIKV), and Yellow Fever Virus (YFV) are prevalent arboviruses in the Americas. Each of these infections is associated with the development of associated disease immunopathology. Immunopathological processes are an outcome of counter-balancing impacts between effector and regulatory immune mechanisms. In this context, regulatory T cells (Tregs) are key in modulating the immune response and, therefore, in tissue damage control....
• Predictors of plasma leakage among dengue patients in Thailand: A plasma-leak score analysis Thu, 29 Jul 2021 06:00:00 -0400
  Delayed plasma leakage recognition could lead to improper fluid administration resulting in dengue shock syndrome, subsequently, multi-organ failure, and death. This prospective observational study was conducted in Bangkok, Thailand, between March 2018 and February 2020 to determine predictors of plasma leakage and develop a plasma leakage predictive score among dengue patients aged ≥15 years. Of 667 confirmed dengue patients, 318 (47.7%) developed plasma leakage, and 349 (52.3%) had no plasma...
• Target product profile for a dengue pre-vaccination screening test Thu, 29 Jul 2021 06:00:00 -0400
  With increasing geographic spread, frequency, and magnitude of outbreaks, dengue continues to pose a major public health threat worldwide. Dengvaxia, a dengue live-attenuated tetravalent vaccine, was licensed in 2015, but post hoc analyses of long-term data showed serostatus-dependent vaccine performance with an excess risk of hospitalized and severe dengue in seronegative vaccine recipients. The World Health Organization (WHO) recommended that only persons with evidence of past dengue infection...
• Reducing mosquito-borne disease transmission to humans: A systematic review of cluster randomised controlled studies that assess interventions other than non-targeted insecticide Thu, 29 Jul 2021 06:00:00 -0400
  CONCLUSION: High community engagement is vital for a cRCT reducing mosquito-borne disease with a mosquito control intervention. These findings support a mosquito breeding source reduction intervention for Aedes control in a future study of Buruli ulcer prevention if local communities are supportive and very engaged. Regular administration of larvicide to sites unsuited to source reduction may supplement the intervention.
• Arboviral Diseases and COVID-19 Coincidence: Challenges for Pakistan's Derelict Healthcare System Thu, 29 Jul 2021 06:00:00 -0400
  No abstract
• Paradigm Shift in Socio-Demographic Profile of Dengue Infection: A Hospital Based Cross-Sectional Study Thu, 29 Jul 2021 06:00:00 -0400
  CONCLUSION: The study highlights the need to curb the rural spread of the disease through activities in creating awareness among all section of people to promote control measures and early reporting of all fever cases, capacity building of rural doctors for early detection, treatment and early referral of high-risk patients and availability of ELISA based tests in sub-district hospitals along with Rapid Diagnostic Kits (RDKs). Emphasis for preventive and control measures to be increased during...