Dengue Virus Net is the web resource for anyone interested in dengue. Dengue is a mosquito-borne infection that causes a severe flu-like illness (dengue fever), and sometimes a potentially lethal complication called dengue haemorrhagic fever. Global incidence of dengue has grown dramatically in recent decades. About two fifths of the world's population are now at risk. Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas. Dengue is transmitted to humans by the Aedes aegypti or more rarely the Aedes albopictus mosquito, which feed during the day. Dengue haemorrhagic fever is a leading cause of serious illness and death among children in some Asian countries. A vaccine for dengue fever has been approved by the FDA in May 2019 and is commercially available in a number of countries.

The objectives of Dengue Virus Net are to be the public and professional information resource for dengue and to serve as a network in the exchange of information and news related to dengue.

• Pakistan: Dengue outbreak worsens, cases exceed 30,000 this year - Hindustan Times
  Sat, 01 Oct 2022 14:05 GMT
• Infected with dengue? Telemedicine can be an option when hospitals close - The Kathmandu Post
  Sun, 02 Oct 2022 02:29 GMT
• Dengue cases lowest in 3 yrs, malaria on rise in Ludhiana - The Tribune India
  Sat, 01 Oct 2022 05:34 GMT
• Dengue kills two more in Karachi, Peshawar as hundreds infected - Daily Minute Mirror
  Sat, 01 Oct 2022 12:49 GMT
• Dengue caused another six deaths of children in August - Dominican Today
  Thu, 08 Sep 2022 07:21 GMT
• Possible health worker shortage during festivals may put dengue patients at risk - The Kathmandu Post
  Fri, 30 Sep 2022 02:20 GMT
• Impact of climate change attributed to dengue cases in mountainous districts in Karnali Province - Myrepublica
  Sat, 01 Oct 2022 10:25 GMT
• Malaysia: Dengue cases more than double in 2022 - Outbreak News Today - Outbreak News Today
  Fri, 30 Sep 2022 22:56 GMT
• Species-specific climate Suitable Conditions Index and dengue transmission in Guangdong, China - Parasites & Vectors - Parasites & Vectors
  Tue, 27 Sep 2022 19:00 GMT
• Efficacy of Dengue Vaccines in the Prevention of Severe Dengue in Children: A Systematic Review - Cureus
  Wed, 07 Sep 2022 07:00 GMT
• Dengue in France: tropical diseases in Europe may not be that rare for much longer - The Conversation Indonesia
  Fri, 23 Sep 2022 15:03 GMT
• Asia's “twindemic”: dengue fever cases rocket as covid-19 rages on - The BMJ
  Mon, 12 Sep 2022 07:00 GMT
• KMC, BMC seek club help in dengue battle - Times of India
  Sun, 02 Oct 2022 02:40 GMT
• ‘Dengue seems to have replaced Covid-19’: With stagnating flood water, Pakistan faces fresh crisis - Scroll.in
  Thu, 29 Sep 2022 14:00 GMT
• KP records year's highest single day dengue cases - DAWN.com
  Sun, 02 Oct 2022 02:30 GMT

• PRO/AH/EDR> Invasive mosquito - France (03): (BT)
  Mon, 06 Sep 2021 21:28:53 -0400
  Yellow Fever, Zika virus, Dengue, Chikungunya -- France
  A potentially deadly mosquito that can carry viruses such as yellow fever and Zika has been spotted in Brittany, northern France, sparking fears they may soon land on British shores. Asian tiger mosquitoes [_Aedes albopictus_] have been confirmed to be in the commune of Domagne in the department of Ile-et-Vilaine in western Brittany.
  Health authorities are preparing an intensive campaign to rid the area of the insects with strong insecticides.
  The creatures were 1st seen in France in the

• Efficacy of native cyclopoid copepods in biological vector control with regard to their predatory behavior against the Asian tiger mosquito, Aedes albopictus Sat, 01 Oct 2022 06:00:00 -0400
  CONCLUSIONS: The results indicate a high predation potential of M. viridis against Ae. albopictus larvae, even though strong larval stage and mosquito species preferences were implicated. The integration of copepods as a promising biocontrol agent to the vector control strategy in Germany is therefore highly recommended, especially because of the excellent compatibility of copepods with the use of Bti. However, further research is required, concerning all the probable parameters that may impact...
• Estimating the effect of the wMel release programme on the incidence of dengue and chikungunya in Rio de Janeiro, Brazil: a spatiotemporal modelling study Sat, 01 Oct 2022 06:00:00 -0400
  BACKGROUND: Introgression of genetic material from species of the insect bacteria Wolbachia into populations of Aedes aegypti mosquitoes has been shown in randomised and non-randomised trials to reduce the incidence of dengue; however, evidence for the real-world effectiveness of large-scale deployments of Wolbachia-infected mosquitoes for arboviral disease control in endemic settings is still scarce. A large Wolbachia (wMel strain) release programme was implemented in 2017 in Rio de Janeiro,...
• COVID-19 and dengue coinfection in Veracruz, Mexico Fri, 30 Sep 2022 06:00:00 -0400
  No abstract
• Flavivirus NS4B protein: Structure, function, and antiviral discovery Fri, 30 Sep 2022 06:00:00 -0400
  Infections with mosquito-borne flaviviruses, such as Dengue virus, ZIKV virus, and West Nile virus, pose significant threats to public health. Flaviviruses cause about 400 million infections each year, leading to many forms of diseases, including fatal hemorrhagic, encephalitis, congenital abnormalities, and deaths. Currently, there are no clinically approved antiviral drugs for the treatment of flavivirus infections. The non-structural protein NS4B is an emerging target for drug discovery due...
• Global trends in research on the effects of climate change on Aedes aegypti: international collaboration has increased, but some critical countries lag behind Thu, 29 Sep 2022 06:00:00 -0400
  CONCLUSIONS: We conclude that some of the countries at risk of expanding Ae. aegypti populations have poor research networks that need to be strengthened. A number of mechanisms can be considered for the improvement of international collaboration, representativity and diversity, such as research networks, internationalization programs, and programs that enhance representativity. These types of collaboration are considered important to expand the relevant knowledge of these countries and for the...
• Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication Thu, 29 Sep 2022 06:00:00 -0400
  The mechanistic target of rapamycin (mTOR) functions in two distinct complexes: mTORC1, and mTORC2. mTORC1 has been implicated in the pathogenesis of flaviviruses including dengue, where it contributes to the establishment of a pro-viral autophagic state. Activation of mTORC2 occurs upon infection with some viruses, but its functional role in viral pathogenesis remains poorly understood. In this study, we explore the consequences of a physical protein-protein interaction between dengue...
• Nucleic Acid Quantification with Amplicon Yield in Recombinase Polymerase Amplification Wed, 28 Sep 2022 06:00:00 -0400
  Amplification-based quantitative polymerase chain reaction (qPCR) provides accurate and sensitive nucleic acid quantification. However, the requirement of temperature cycling and real-time monitoring limits its translation to many settings. Quantitative isothermal amplification methods alleviate the need for thermal cyclers; however, they still require continuous monitoring of the nucleic acid amplification on sophisticated readers. Here, we adapted an isothermal recombinase polymerase...
• Comprehensive Molecular Interaction Studies to Construe the Repellent/Kill Activity of Geraniol During Binding Event Against Aedes aegypti Proteins Wed, 28 Sep 2022 06:00:00 -0400
  Aedes aegypti is an etiological agent for dengue, chikungunya, zika, and yellow fever viruses. With the advent of the use of natural alternatives as repellents, their precise mode of action during the event of binding is still unclear. Geraniol is one such bioactive natural that has been previously shown to have some insecticide properties. Thus, the present study aimed to understand the mechanism of the binding event of geraniol with the whole proteome of A. aegypti. Twenty protein target...
• Factors associated with deaths from dengue in a city in a metropolitan region in Southeastern Brazil: a case-control study Wed, 28 Sep 2022 06:00:00 -0400
  CONCLUSIONS: The results showed that age and the presence of bleeding factors increased the risk of dengue death. These findings indicate that warning signs of dengue should be routinely monitored, and patients should be instructed to seek medical attention when they occur. It is also emphasized that the parameters and epidemiological conditions of dengue patients need to be continuously investigated to avoid a fatal outcome.
• Hospital admissions due to neglected tropical diseases in Piauí, in the Northeast region of Brazil: costs, time trends, and spatial patterns, 2001-2018 Wed, 28 Sep 2022 06:00:00 -0400
  To characterize the magnitude of hospital admissions and costs of patients with neglected tropical diseases, their time trends, and spatial patterns in Piauí, in the Northeast Region of Brazil, in 2001-2018. Ecological study of mixed designs, with calculation of relative risk (RR), time-trend analysis by Poisson regression, and inflection points, using data from neglected tropical diseases Hospital Admission Authorizations available in the Hospital Information System of the Brazilian Unified...