Dengue Virus Net is the web resource for anyone interested in dengue. Dengue is a mosquito-borne infection that causes a severe flu-like illness (dengue fever), and sometimes a potentially lethal complication called dengue haemorrhagic fever. Global incidence of dengue has grown dramatically in recent decades. About two fifths of the world's population are now at risk. Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas. Dengue is transmitted to humans by the Aedes aegypti or more rarely the Aedes albopictus mosquito, which feed during the day. Dengue haemorrhagic fever is a leading cause of serious illness and death among children in some Asian countries. A vaccine for dengue fever has been approved by the FDA in May 2019 and is commercially available in a number of countries.

The objectives of Dengue Virus Net are to be the public and professional information resource for dengue and to serve as a network in the exchange of information and news related to dengue.

• Risk Predictors of Dengue Disease Progression During the Febrile Phase - Infectious Disease Advisor
  Fri, 30 Apr 2021 15:25 GMT
• Epidemiology of dengue virus infections in Nepal, 2006–2019 | Infectious Diseases of Poverty | Full Text - Infectious Diseases of Poverty - BioMed Central
  Thu, 15 Apr 2021 07:00 GMT
• Brazil at high risk of dengue outbreaks after droughts because of temporary water storage - EurekAlert
  Thu, 08 Apr 2021 07:00 GMT
• Global Dengue Vaccines Disease Market Analysis Report 2021-2022: Dengvaxia's Uptake will Remain Minimal Before Pipeline - GlobeNewswire
  Mon, 19 Apr 2021 07:00 GMT
• Yellow Fever Vaccine Market: Rising prevalence of dengue to drive the market - BioSpace
  Tue, 27 Apr 2021 07:00 GMT
• Dengue prevention and the acceptance to dengue vaccination | PPA - Dove Medical Press
  Thu, 15 Apr 2021 07:00 GMT
• Cook Islands dengue outbreak now 162 cases, dozens hospitalized - Outbreak News Today - Outbreak News Today
  Tue, 27 Apr 2021 07:00 GMT
• JTFB donates foggers to fight dengue in La Paz - U.S. Southern Command
  Thu, 22 Apr 2021 07:00 GMT
• Zero dengue cases in Guimaras for 7 weeks - Panay News
  Wed, 05 May 2021 21:34 GMT
• NEA urges continued vigilance against dengue even as situation in Singapore appears to be easing - The Straits Times
  Thu, 29 Apr 2021 09:32 GMT
• In the US, Imminent Release of Genetically Modified Mosquitoes To Fight Dengue - The Wire Science
  Wed, 14 Apr 2021 07:00 GMT
• Dengue cases in the Cook Islands on the increase - RNZ
  Mon, 26 Apr 2021 07:00 GMT
• Dengue Treatment - The Importance of Getting Into Clinical Trials - - VENTS Magazine
  Mon, 03 May 2021 13:34 GMT
• Global Dengue Vaccines Disease Analysis Report 2021-2022: Approvals of TV003/TV005 and Domestic Vaccines will Lead to Considerable Competition - ResearchAndMarkets.com - Business Wire
  Thu, 15 Apr 2021 07:00 GMT
• Tracking mosquito larvae to prevent Dengue, Chikungunya spikes - CGTN
  Sun, 02 May 2021 14:48 GMT

• PRO> Vector mosquito control - USA: (FL)
  Wed, 05 May 2021 17:31:47 -0400
  Other Human Disease -- United States
  After a decade of fighting for regulatory approval and public acceptance, a biotechnology firm has released genetically engineered mosquitoes into the open air in the United States for the first time. The experiment, launched this week in the Florida Keys (over the objections of some local critics), tests a method for suppressing populations of wild _Aedes aegypti_ mosquitoes, which can carry diseases such as Zika, dengue, chikungunya and yellow fever.
  Oxitec, the firm based in Abingdon,

• Incidence of dengue illness in Mexican people aged 6 months to 50 years old: A prospective cohort study conducted in Jalisco Wed, 05 May 2021 06:00:00 -0400
  CONCLUSION: Community-based active surveillance was shown as efficient to detect symptomatic dengue cases.
• Global patterns of aegyptism without arbovirus Wed, 05 May 2021 06:00:00 -0400
  The world's most important mosquito vector of viruses, Aedes aegypti, is found around the world in tropical, subtropical and even some temperate locations. While climate change may limit populations of Ae. aegypti in some regions, increasing temperatures will likely expand its territory thus increasing risk of human exposure to arboviruses in places like Europe, Northern Australia and North America, among many others. Most studies of Ae. aegypti biology and virus transmission focus on locations...
• Use of Cerebrospinal Fluid for the Diagnosis of Neuroinvasive Dengue, Zika, and Chikungunya: A 19-year systematic review Wed, 05 May 2021 06:00:00 -0400
  CONCLUSIONS: Although cerebrospinal fluid analysis is of great importance for increasing neurological diagnostic accuracy and contributes to the early diagnosis of neuroinvasive dengue, chikungunya, and Zika infections, it is underused in routine laboratory investigations worldwide.
• Machine Learning in Discovery of New Antivirals and Optimization of Viral Infections Therapy Wed, 05 May 2021 06:00:00 -0400
  Nowadays, computational approaches play an important role in the design of new drug-like compounds and optimization of pharmacotherapeutic treatment of diseases. The emerging growth of viral infections, including those caused by the Human Immunodeficiency Virus (HIV), Ebola virus, recently detected coronavirus, and some others, leads to many newly infected people with a high risk of death or severe complications. A huge amount of chemical, biological, clinical data is at the disposal of the...
• Reactive oxygen species as potential antiviral targets Wed, 05 May 2021 06:00:00 -0400
  Reactive oxygen species (ROS) are by-products of cellular metabolism and can be either beneficial, at low levels, or deleterious, at high levels, to the cell. It is known that several viral infections can increase oxidative stress, which is mainly facilitated by viral-induced imbalances in the antioxidant defence mechanisms of the cell. While the exact role of ROS in certain viral infections (adenovirus and dengue virus) remains unknown, other viruses can use ROS for enhancement of pathogenesis...
• Using Data Mining and Network Analysis to Infer Arboviral Dynamics: The Case of Mosquito-Borne Flaviviruses Reported in Mexico Wed, 05 May 2021 06:00:00 -0400
  Given the significant impact of mosquito-borne flaviviruses (MBFVs) on both human and animal health, predicting their dynamics and understanding their transmission cycle is of the utmost importance. Usually, predictions about the distribution of priority pathogens, such as Dengue, Yellow fever, West Nile Virus and St. Louis encephalitis, relate abiotic elements to simple biotic components, such as a single causal agent. Furthermore, focusing on single pathogens neglects the possibility of...
• Analysis of a Routinely Used Commercial Anti-Chikungunya IgM ELISA Reveals Cross-Reactivities with Dengue in Brazil: A New Challenge for Differential Diagnosis? Wed, 05 May 2021 06:00:00 -0400
  In Brazil, chikungunya emerged in 2014, and by 2016, co-circulated with other arbovirosis, such as dengue and zika. ELISAs (Enzyme-Linked Immunosorbent Assays) are the most widely used approach for arboviruses diagnosis. However, some limitations include antibody cross reactivities when viruses belong to the same genus, and sensitivity variations in distinct epidemiological scenarios. As chikungunya virus (CHIKV) is an alphavirus, no serological cross reactivity with dengue virus (DENV) should...
• Trimerization of the N-Terminal Tail of Zika Virus NS4A Protein: A Potential In Vitro Antiviral Screening Assay Wed, 05 May 2021 06:00:00 -0400
  The nonstructural (NS) protein NS4A in flaviviruses is a membrane protein that is critical for virulence, and, among other roles, it participates in membrane morphogenesis. In dengue virus (DENV), the NS4A hydrophilic N-terminal tail, together with the first transmembrane domain, is involved in both homo-oligomerization and hetero-oligomerization with NS4B. In both DENV and Zika virus (ZIKV), this N-terminal tail (residues 1-48) forms a random coil in solution but becomes mostly α-helical upon...
• Immunological analysis of the murine anti-CD3-induced cytokine release syndrome model and therapeutic efficacy of anti-cytokine antibodies Tue, 04 May 2021 06:00:00 -0400
  The aberrant release of inflammatory mediators often referred to as a cytokine storm or cytokine release syndrome (CRS), is a common and sometimes fatal complication in acute infectious diseases including Ebola, dengue, COVID-19 and influenza. Fatal CRS occurrences have also plagued the development of highly promising cancer therapies based on T cell engagers and chimeric antigen receptor (CAR) T cells. CRS is intimately linked with dysregulated and excessive cytokine release including...
• Natural Vertical Transmission of Dengue Virus Serotype 4 in Aedes aegypti Larvae from Urban Areas in Sinaloa, Mexico Tue, 04 May 2021 06:00:00 -0400
  Dengue virus (DENV) is transmitted to humans by the bite of the vector Aedes aegypti. Several researchers have suggested that the mechanism of vertical transmission of DENV in the vector is a key aspect for the prevalence of the virus in the environment and the potentiation of epidemic outbreaks of the disease. In this context and as part of an integrated study of DENV serotypes in mosquitoes of urban areas in Sinaloa, Mexico, the presence of DENV-4 in larval stages of Ae. aegypti was evaluated...